XVIRUS.ORG

Mathematical cytokine storm simulators for viral haemorrhagic fever — open-source clinical decision support during active outbreaks

Active outbreak: Andes hantavirus (MV Hondius, April–May 2026) — 7 confirmed cases, 3 deaths across 6 countries. WHO Level 3.
PHEIC declared 16 May 2026:Bundibugyo ebolavirus (Ituri Province DRC & Uganda) — 500+ suspected cases, 131+ deaths. No approved vaccine or treatment.
HPS Simulator
Andes orthohantavirus · ANDV

Cytokine storm dynamics in hantavirus pulmonary syndrome. 14-variable ODE model — Schur complement storm threshold, Wasserstein early-warning score, CTL-mediated VEGF pathway.

1.875Loop gain ℛᵢₚ
2.5Alert W threshold
35–40%CFR (ANDV)
Open HPS Simulator →
BVD Simulator
Bundibugyo ebolavirus · PHEIC 2026

Cytokine storm dynamics in Bundibugyo virus disease. BVD-calibrated parameters — loop gain 2.6× higher than HPS, lower alert threshold, faster storm progression. No approved treatment exists.

4.86Loop gain ℛᵢₚ
1.8Alert W threshold
30–50%CFR (BVD)
Open BVD Simulator →
↗ medRxiv preprint↗ Source code (MIT)↗ Quantum Proteins AI↗ Contact

These simulators are mathematical decision-support tools based on published immunological parameters. They are not approved medical devices and do not constitute clinical protocols. All recommendations should be validated by qualified infectious disease specialists.